Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50017655
Substrate
n/a
Meas. Tech.
ChEMBL_2446906
Ki
3.2±n/a nM
Citation
 Dorogan, M; Namballa, HK; Harding, WW Natural Product-Inspired Dopamine Receptor Ligands. J Med Chem 67:12463-12484[PubMed] 
Target
Name:
D(3) dopamine receptor
Synonyms:
Dopamine D3 receptor | DRD3_HUMAN | DRD3
Type:
PROTEIN
Mol. Mass.:
44213.40
Organism:
Human
Description:
ChEMBL_105671
Residue:
400
Sequence:
MASLSQLSGHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50017655
Synonyms:
2-{4-[3-(2-Trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol (Fluphenazine) | 2-{4-[3-(2-Trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol | Flufenazine | 2-(4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol | Permitil | Prolixin | CHEMBL726 | FLUPHENAZINE
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Structure:
Search PDB for entries with ligand similarity: