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Target
Histone-lysine N-methyltransferase SUV39H1
Ligand
BDBM50315537
Substrate
n/a
Meas. Tech.
ChEMBL_2454798
IC50
800±n/a nM
Citation
 Hassanie, H; Penteado, AB; de Almeida, LC; Calil, RL; da Silva Emery, F; Costa-Lotufo, LV; Trossini, GHG SETDB1 as a cancer target: challenges and perspectives in drug design. RSC Med Chem 15:1424-1451[PubMed] 
Target
Name:
Histone-lysine N-methyltransferase SUV39H1
Synonyms:
H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1 | SUV91_HUMAN | SUV39H1 | KMT1A | SUV39H
Type:
PROTEIN
Mol. Mass.:
47917.07
Organism:
Human
Description:
ChEMBL_1473655
Residue:
412
Sequence:
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
  
Inhibitor
Name:
BDBM50315537
Synonyms:
chaetocin | CHEMBL1089316
Type:
Small organic molecule
Emp. Form.:
C30 H28 N6 O6 S4
Mol. Mass.:
696.83992
SMILES:
CN1C(=O)[C@@]23C[C@]4([C@]56C[C@@]78SS[C@@](CO)(C(=O)N7[C@H]5Nc5ccccc56)N(C)C8=O)c5ccccc5N[C@@H]4N2C(=O)[C@]1(CO)SS3
Structure:
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