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Target
Substance-P receptor
Ligand
BDBM50087852
Substrate
n/a
Meas. Tech.
ChEMBL_452917 (CHEMBL903160)
IC50
32±n/a nM
Citation
 Beard, DJ; Perrine, SA; Phillips, E; Hoque, S; Conerly, S; Tichenor, C; Simmons, MA; Young, JK Conformational comparisons of a series of tachykinin peptide analogs. J Med Chem 50:6501-6 (2007) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
SPR | Substance-P receptor | NK-1R | Tachykinin receptor 1 | NK-1 receptor | Neurokinin NK1 | NK1 Receptor | NK1R_RAT | Tacr1 | Tac1r | Neurokinin 1 receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46371.54
Organism:
Rat
Description:
Competition binding assays were carried out using membrane preparations from transfected CHO cells that constitutively expressed the rat NK1 receptor.
Residue:
407
Sequence:
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
  
Inhibitor
Name:
BDBM50087852
Synonyms:
His-Asn-Pro-Ala-Ser-Phe-Ile-Gly-Leu-Met-NH2 | HisAsnProAlaSerPheIleGlyLeuMet | CHEMBL263185
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O
Structure:
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