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Target
Adenosine receptor A2a
Ligand
BDBM21172
Substrate
n/a
Meas. Tech.
ChEMBL_460910 (CHEMBL943937)
Ki
26±n/a nM
Citation
 Slee, DH; Zhang, X; Moorjani, M; Lin, E; Lanier, MC; Chen, Y; Rueter, JK; Lechner, SM; Markison, S; Malany, S; Joswig, T; Santos, M; Gross, RS; Williams, JP; Castro-Palomino, JC; Crespo, MI; Prat, M; Gual, S; Díaz, JL; Wen, J; O'Brien, Z; Saunders, J Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy. J Med Chem 51:400-6 (2008) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
ADENOSINE A2a | Rat striatal adenosine A2a receptor | Adenosine A2a receptor (A2a) | Adenosine receptors A2a | AA2AR_RAT | Adora2a | Adenosine receptor A2a and A3 | Adenosine Receptors A2a (A2a) | Adenosine A2 receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rat
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM21172
Synonyms:
CHEMBL251975 | N-[2-(furan-2-yl)-6-(1H-pyrazol-1-yl)pyrimidin-4-yl]-2-(4-methylpiperazin-1-yl)acetamide | Pyrimidine analogue, 1
Type:
Small organic molecule
Emp. Form.:
C18H21N7O2
Mol. Mass.:
367.18
SMILES:
CN1CCN(CC(=O)Nc2cc(nc(n2)-c2ccco2)-n2cccn2)CC1
Structure:
Search PDB for entries with ligand similarity: