Reaction Details Report a problem with these data
Target
Autoinducer 2-binding periplasmic protein LuxP
Ligand
BDBM50206006
Substrate
n/a
Meas. Tech.
ChEMBL_462614 (CHEMBL929603)
IC50
12000±n/a nM
Citation
 Ni, N; Choudhary, G; Li, M; Wang, B Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi. Bioorg Med Chem Lett 18:1567-72 (2008) [PubMed]  Article 
Target
Name:
Autoinducer 2-binding periplasmic protein LuxP
Synonyms:
LUXP_VIBHA | luxP
Type:
PROTEIN
Mol. Mass.:
41453.75
Organism:
Vibrio harveyi
Description:
ChEMBL_1513759
Residue:
365
Sequence:
MKKALLFSLISMVGFSPASQATQVLNGYWGYQEFLDEFPEQRNLTNALSEAVRAQPVPLSKPTQRPIKISVVYPGQQVSDYWVRNIASFEKRLYKLNINYQLNQVFTRPNADIKQQSLSLMEALKSKSDYLIFTLDTTRHRKFVEHVLDSTNTKLILQNITTPVREWDKHQPFLYVGFDHAEGSRELATEFGKFFPKHTYYSVLYFSEGYISDVRGDTFIHQVNRDNNFELQSAYYTKATKQSGYDAAKASLAKHPDVDFIYACSTDVALGAVDALAELGREDIMINGWGGGSAELDAIQKGDLDITVMRMNDDTGIAMAEAIKWDLEDKPVPTVYSGDFEIVTKADSPERIEALKKRAFRYSDN
  
Inhibitor
Name:
BDBM50206006
Synonyms:
7,8-Dihydroxy-2H-1-benzopyran-2-one | 7,8-dihydroxy-2H-chromen-2-one | 7,8-dihydroxycoumarin | CHEMBL244948 | Daphnetol
Type:
Small organic molecule
Emp. Form.:
C9H6O4
Mol. Mass.:
178.1415
SMILES:
Oc1ccc2ccc(=O)oc2c1O
Structure:
Search PDB for entries with ligand similarity: