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Target
Serine/threonine-protein kinase Nek8
Ligand
BDBM50337134
Substrate
n/a
Meas. Tech.
ChEMBL_2526561
IC50
>50000±n/a nM
Citation
 Yang, Q; Deng, X; Lu, B; Cameron, M; Fearns, C; Patricelli, MP; Yates, JR; Gray, NS; Lee, JD Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell 18:258-67[PubMed] 
Target
Name:
Serine/threonine-protein kinase Nek8
Synonyms:
2.7.11.1 | Never in mitosis A-related kinase 8 | NimA-related protein kinase 8 | Nima-related protein kinase 12a | Serine/threonine-protein kinase Nek8 | NEK8_HUMAN | NEK8 | JCK | NEK12A
Type:
PROTEIN
Mol. Mass.:
74819.06
Organism:
Human
Description:
ChEMBL_119768
Residue:
692
Sequence:
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
  
Inhibitor
Name:
BDBM50337134
Synonyms:
US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | 2-((2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
Type:
Small organic molecule
Emp. Form.:
C26H30N6O3
Mol. Mass.:
n/a
SMILES:
CCOc1cc(ccc1Nc2ncc3c(n2)N(c4ccccc4C(=O)N3C)C)N5CCC(CC5)O
Structure:
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