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Target
Histone H4
Ligand
BDBM50365463
Substrate
n/a
Meas. Tech.
ChEMBL_2563478
IC50
>10000±n/a nM
Citation
 Dawson, MA; Prinjha, RK; Dittmann, A; Giotopoulos, G; Bantscheff, M; Chan, WI; Robson, SC; Chung, CW; Hopf, C; Savitski, MM; Huthmacher, C; Gudgin, E; Lugo, D; Beinke, S; Chapman, TD; Roberts, EJ; Soden, PE; Auger, KR; Mirguet, O; Doehner, K; Delwel, R; Burnett, AK; Jeffrey, P; Drewes, G; Lee, K; Huntly, BJ; Kouzarides, T Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478:529-33[PubMed] 
Target
Name:
Histone H4
Synonyms:
andH4/M | and | andH4/N | andH4/O | andH4/B | andH4/C | andH4/H | andH4/I | andH4/J | andH4/K | andH4/D | andH4/E | andH4/G | H4_HUMAN | H4C1 | H4/A | H4FA | HIST1H4A | H4/I | H4FI | HIST1H4B | H4/G | H4FG | HIST1H4C | H4/B | H4FB | HIST1H4D | H4/J | H4FJ | HIST1H4E | H4/C | H4FC | HIST1H4F | H4/H | H4FH | HIST1H4H | H4/M | H4FM | HIST1H4I | H4/E | H4FE | HIST1H4J | H4/D | H4FD | HIST1H4K | H4/K | H4FK | HIST1H4L | H4/N | H4F2 | H4FN | HIST2H4 | HIST2H4A | H4/O | H4FO | HIST2H4B | H4-16 | HIST4H4
Type:
Protein
Mol. Mass.:
11386.36
Organism:
Human
Description:
P62805
Residue:
103
Sequence:
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
  
Inhibitor
Name:
BDBM50365463
Synonyms:
CHEMBL1232461
Type:
Small organic molecule
Emp. Form.:
C22H22ClN5O2
Mol. Mass.:
n/a
SMILES:
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12 |r,t:7|
Structure:
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