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Target
Protein kinase C-binding protein 1
Ligand
BDBM50365463
Substrate
n/a
Meas. Tech.
ChEMBL_2563723
IC50
110±n/a nM
Citation
 Dawson, MA; Prinjha, RK; Dittmann, A; Giotopoulos, G; Bantscheff, M; Chan, WI; Robson, SC; Chung, CW; Hopf, C; Savitski, MM; Huthmacher, C; Gudgin, E; Lugo, D; Beinke, S; Chapman, TD; Roberts, EJ; Soden, PE; Auger, KR; Mirguet, O; Doehner, K; Delwel, R; Burnett, AK; Jeffrey, P; Drewes, G; Lee, K; Huntly, BJ; Kouzarides, T Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 478:529-33[PubMed] 
Target
Name:
Protein kinase C-binding protein 1
Synonyms:
CTCL-associated antigen se14-3 | Cutaneous T-cell lymphoma-associated antigen se14-3 | Zinc finger MYND domain-containing protein 8 | ZMYD8_HUMAN | ZMYND8 | KIAA1125 | PRKCBP1 | RACK7
Type:
PROTEIN
Mol. Mass.:
131701.11
Organism:
Human
Description:
ChEMBL_109902
Residue:
1186
Sequence:
MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQGSDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD
  
Inhibitor
Name:
BDBM50365463
Synonyms:
CHEMBL1232461
Type:
Small organic molecule
Emp. Form.:
C22H22ClN5O2
Mol. Mass.:
n/a
SMILES:
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12 |r,t:7|
Structure:
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