Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase EZH2
Ligand
BDBM50442103
Substrate
n/a
Meas. Tech.
ChEMBL_2577567
IC50
5000±n/a nM
Citation
 Zhang, XY; Rajagopalan, D; Chung, TH; Hooi, L; Toh, TB; Tian, JS; Rashid, MBMA; Sahib, NRBM; Gu, M; Lim, JJ; Wang, W; Chng, WJ; Jha, S; Chow, EK Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma. Exp Hematol Oncol 9:0[PubMed] 
Target
Name:
Histone-lysine N-methyltransferase EZH2
Synonyms:
Enhancer of zeste homolog 2 (EZH2) | ENX-1 | Lysine N-methyltransferase 6 | EZH2_HUMAN | EZH2 | KMT6 | Histone-lysine N-methyltransferase EZH2
Type:
Protein
Mol. Mass.:
85367.84
Organism:
Human
Description:
Q15910
Residue:
746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
  
Inhibitor
Name:
BDBM50442103
Synonyms:
CHEMBL2441082
Type:
Small organic molecule
Emp. Form.:
C29H44F2N6O2
Mol. Mass.:
546.7
SMILES:
COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCC(F)(F)CC1
Structure:
Search PDB for entries with ligand similarity: