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Target
Serine/threonine-protein kinase Nek8
Ligand
BDBM130909
Substrate
n/a
Meas. Tech.
ChEMBL_2583318
IC50
3.1±n/a nM
Citation
 Deng, C; Lipstein, MR; Scotto, L; Jirau Serrano, XO; Mangone, MA; Li, S; Vendome, J; Hao, Y; Xu, X; Deng, SX; Realubit, RB; Tatonetti, NP; Karan, C; Lentzsch, S; Fruman, DA; Honig, B; Landry, DW; O'Connor, OA Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies. Blood 129:88-99[PubMed] 
Target
Name:
Serine/threonine-protein kinase Nek8
Synonyms:
2.7.11.1 | Never in mitosis A-related kinase 8 | NimA-related protein kinase 8 | Nima-related protein kinase 12a | Serine/threonine-protein kinase Nek8 | NEK8_HUMAN | NEK8 | JCK | NEK12A
Type:
PROTEIN
Mol. Mass.:
74819.06
Organism:
Human
Description:
ChEMBL_119768
Residue:
692
Sequence:
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
  
Inhibitor
Name:
BDBM130909
Synonyms:
US8822500, Stauro- sporine | US9920060, Staurosporine | US10683289, Example Staurosporine | US10927120, Compound staurosporine
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
Structure:
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