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Target
Histone-lysine N-methyltransferase EHMT1
Ligand
BDBM50613108
Substrate
n/a
Meas. Tech.
ChEMBL_2615338
IC50
76±n/a nM
Citation
 Mukherjee, A; Suzuki, T G9a/GLP Modulators: Inhibitors to Degraders. J Med Chem 68:953-985[PubMed]
Target
Name:
Histone-lysine N-methyltransferase EHMT1
Synonyms:
Euchromatic histone-lysine N-methyltransferase 1 | Eu-HMTase1 | G9a-like protein 1 | GLP1 | Histone H3-K9 methyltransferase 5 | H3-K9-HMTase 5 | Lysine N-methyltransferase 1D | EHMT1_HUMAN | EHMT1 | EUHMTASE1 | GLP | KIAA1876 | KMT1D | Histone-lysine N-methyltransferase EHMT1/EHMT2
Type:
PROTEIN
Mol. Mass.:
141443.67
Organism:
Human
Description:
ChEMBL_1450367
Residue:
1298
Sequence:
MAAADAEAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSHANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTADDFVQTSVIGSNGYILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSADTEDRKLPAPGADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISDFGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHGAEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIKKKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVSLDSLDLRVKGILSSQAEGLANGPDVLETDGLQEVPLCSCRMETPKSREITTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVTPVPGQEKGSALEGRADTTTGSAAGPPLSEDDKLQGAASHVPEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHSSAALAQRQASAAQEAQEDGLPDTSSAAAADPL
  
Inhibitor
Name:
BDBM50613108
Synonyms:
CHEMBL5266889
Type:
Small organic molecule
Emp. Form.:
C19H25N3O
Mol. Mass.:
311.43
SMILES:
CN1CCCC(=CC1)c2cc3c(cc2OC)C4(CCC4)C(=N3)N
Structure:
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