Reaction Details Report a problem with these data
Target
Deoxyribonuclease-2-alpha
Ligand
BDBM50242374
Substrate
n/a
Meas. Tech.
ChEMBL_509270 (CHEMBL996014)
IC50
>250000±n/a nM
Citation
 Suzuki, K; Yahara, S; Maehata, K; Uyeda, M Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod 64:204-7 (2001) [PubMed]  Article 
Target
Name:
Deoxyribonuclease-2-alpha
Synonyms:
DNS2A_PIG | DNASE2 | DNASE2A | DNL2
Type:
PROTEIN
Mol. Mass.:
40189.42
Organism:
Pig
Description:
ChEMBL_509270
Residue:
364
Sequence:
MATLSPLLLAALLWVPVGTLTCYGDSGQPVDWFVVYKLPAHSSPGDVAQSGLRYKYLDEESGGWRDGAGSINSSTGALGRSLLPLYRNTSQLAFLLYNDQPPKYRGSQHSSNRGHTKGVLLLDQEGGFWLIHSVPNFPPPSSSAAYSWPPSARTYGQTLICVSFPLTQFLNISRQLTYTYPMVYDYKLEGDFARKFPYLEEVVKGHHVLQEPWNSSVTLTSKAGASFQSFAKCGNFGDDLYSGWLAEALGSNLQVQFWQRSAGILPSNCSGVQHVLDVTQIAFPGPAGPNFNATEDHSKWCVAPERPWTCVGDMNRNKREEHRGGGTLCAQLPALWKAFKPLVKAWEPCEKENRAFSPRSPAKD
  
Inhibitor
Name:
BDBM50242374
Synonyms:
topostatin | CHEMBL505529
Type:
Small organic molecule
Emp. Form.:
C36H58N4O11S
Mol. Mass.:
754.38
SMILES:
CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C |r,w:14.14,10.9|
Structure:
Search PDB for entries with ligand similarity: