Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50259896
Substrate
n/a
Meas. Tech.
ChEMBL_526200 (CHEMBL974769)
IC50
37500±n/a nM
Citation
 Puder, CWagner, KVettermann, RHauptmann, RPotterat, O Terphenylquinone inhibitors of the src protein tyrosine kinase from Stilbella sp. J Nat Prod 68:323-6 (2005) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50259896
Synonyms:
2,5-Dihydroxy-3-(4-hydroxyphenyl)-6-phenyl-1,4-benzoquinone | CHEMBL511451
Type:
Small organic molecule
Emp. Form.:
C18H12O5
Mol. Mass.:
308.2849
SMILES:
Oc1ccc(cc1)C1C(=O)C(=O)C(C(=O)C1=O)c1ccccc1 |(22.55,.44,;21.01,.36,;20.3,-1.01,;18.77,-1.08,;17.94,.22,;18.64,1.58,;20.17,1.66,;16.4,.15,;15.57,1.44,;16.27,2.81,;14.03,1.37,;13.19,2.66,;13.33,0,;14.17,-1.3,;13.46,-2.67,;15.7,-1.22,;16.53,-2.52,;11.79,-.08,;10.95,1.22,;9.42,1.14,;8.71,-.23,;9.54,-1.53,;11.09,-1.46,)|
Structure:
Search PDB for entries with ligand similarity: