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Target
Estrogen receptor
Ligand
BDBM50250224
Substrate
n/a
Meas. Tech.
ChEMBL_527053 (CHEMBL632930)
IC50
29000±n/a nM
Citation
 Ito, C; Itoigawa, M; Kumagaya, M; Okamoto, Y; Ueda, K; Nishihara, T; Kojima, N; Furukawa, H Isoflavonoids with antiestrogenic activity from Millettia pachycarpa. J Nat Prod 69:138-41 (2006) [PubMed]  Article  BDB Entry
Target
Name:
Estrogen receptor
Synonyms:
ER | ER-alpha | ESR | ESR1 | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1
Type:
Protein
Mol. Mass.:
66230.44
Organism:
Homo sapiens (Human)
Description:
P03372
Residue:
595
Sequence:
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
  
Inhibitor
Name:
BDBM50250224
Synonyms:
(+/-)-3-(3',4'-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one | CHEMBL522471
Type:
Small organic molecule
Emp. Form.:
C25H26O7
Mol. Mass.:
438.4697
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]-[#6](-[#8])-[#6](-[#6])=[#6])c(-[#8])c2c1occ(-c1ccc(-[#8])c(-[#8])c1)c2=O
Structure:
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