Reaction Details Report a problem with these data
Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50260245
Substrate
n/a
Meas. Tech.
ChEMBL_509302 (CHEMBL996874)
Ki
287±n/a nM
Citation
 Chen, D; Liao, J; Li, N; Zhou, C; Liu, Q; Wang, G; Zhang, R; Zhang, S; Lin, L; Chen, K; Xie, X; Nan, F; Young, AA; Wang, MW A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A 104:943-8 (2007) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50260245
Synonyms:
1,3-bis(4-(cyclopentanecarboxamido)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid | CHEMBL510593
Type:
Small organic molecule
Emp. Form.:
C56H52N4O14S2
Mol. Mass.:
1069.16
SMILES:
COc1cc(ccc1OC(=O)c1cccs1)C1C(NC(=O)c2ccc(NC(=O)C3CCCC3)cc2)(C(c2ccc(OC(=O)c3cccs3)c(OC)c2)C1(NC(=O)c1ccc(NC(=O)C2CCCC2)cc1)C(O)=O)C(O)=O |(19.44,-26.93,;20.21,-28.27,;21.75,-28.28,;22.52,-26.96,;24.06,-26.97,;24.82,-28.29,;24.05,-29.61,;22.51,-29.61,;21.73,-30.95,;20.19,-30.94,;19.42,-29.6,;19.42,-32.27,;17.89,-32.43,;17.57,-33.94,;18.9,-34.71,;20.05,-33.68,;24.06,-25.41,;25.6,-25.41,;25.61,-26.96,;26.95,-27.73,;28.49,-27.71,;26.94,-29.26,;25.61,-30.03,;25.6,-31.57,;26.92,-32.34,;26.92,-33.88,;25.59,-34.65,;24.26,-33.87,;25.58,-36.19,;24.34,-37.09,;24.8,-38.56,;26.34,-38.56,;26.82,-37.1,;28.27,-31.57,;28.27,-30.04,;25.6,-23.87,;25.59,-22.31,;24.82,-21,;25.59,-19.67,;27.13,-19.66,;27.89,-18.33,;29.43,-18.32,;30.21,-19.66,;30.2,-16.99,;31.73,-16.82,;32.05,-15.32,;30.71,-14.54,;29.56,-15.58,;27.89,-20.99,;29.43,-20.99,;30.21,-22.32,;27.13,-22.32,;24.06,-23.86,;24.04,-22.32,;22.69,-21.56,;21.15,-21.58,;22.69,-20.03,;24.01,-19.25,;24.01,-17.71,;22.68,-16.95,;22.68,-15.41,;24,-14.63,;25.34,-15.4,;24,-13.09,;25.24,-12.18,;24.76,-10.71,;23.22,-10.72,;22.75,-12.19,;21.34,-17.72,;21.35,-19.26,;22.52,-23.86,;21.75,-22.53,;21.74,-25.19,;27.15,-25.43,;27.9,-26.77,;27.93,-24.1,)|
Structure:
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