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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50098391
Substrate
n/a
Meas. Tech.
ChEMBL_555923 (CHEMBL956659)
Ki
0.5±n/a nM
Citation
 Betz, SF; Zhu, YF; Chen, C; Struthers, RS Non-peptide gonadotropin-releasing hormone receptor antagonists. J Med Chem 51:3331-48 (2008) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_MACMU
Type:
PROTEIN
Mol. Mass.:
7087.59
Organism:
Macaca mulatta
Description:
ChEMBL_495156
Residue:
59
Sequence:
VAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50098391
Synonyms:
(S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(pyrimidin-4-yl)-3-(3,4,5-trimethylphenyl)-1,2-dihydroquinoline-6-carboxamide | 4-((S)-2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | 4-(2-Azetidin-2-yl-ethoxy)-7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide | CHEMBL120432
Type:
Small organic molecule
Emp. Form.:
C28H28ClN5O3
Mol. Mass.:
518.007
SMILES:
Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O |r|
Structure:
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