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Target
Cytochrome P450 3A43
Ligand
BDBM50252659
Substrate
n/a
Meas. Tech.
ChEMBL_487752 (CHEMBL1009484)
IC50
1900±n/a nM
Citation
 Jin, J; An, M; Sapienza, A; Aiyar, N; Naselsky, D; Sarau, HM; Foley, JJ; Salyers, KL; Knight, SD; Keenan, RM; Rivero, RA; Dhanak, D; Douglas, SA Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides. Bioorg Med Chem Lett 18:3950-4 (2008) [PubMed]  Article 
Target
Name:
Cytochrome P450 3A43
Synonyms:
CP343_HUMAN | CYP3A43 | Cytochrome P450 3A | Cytochrome P450 3A43
Type:
PROTEIN
Mol. Mass.:
57676.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_487752
Residue:
503
Sequence:
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
  
Inhibitor
Name:
BDBM50252659
Synonyms:
(S)-N-(1-(3-bromo-4-(piperidin-4-yloxy)benzyl)pyrrolidin-3-yl)-3,4-dichlorobenzamide | CHEMBL495075
Type:
Small organic molecule
Emp. Form.:
C23H26BrCl2N3O2
Mol. Mass.:
527.281
SMILES:
Clc1ccc(cc1Cl)C(=O)N[C@H]1CCN(Cc2ccc(OC3CCNCC3)c(Br)c2)C1 |r|
Structure:
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