Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM50262596
Substrate
n/a
Meas. Tech.
ChEMBL_489248 (CHEMBL989995)
Kd
300000±n/a nM
Citation
Prakesch, M; Denisov, AY; Naim, M; Gehring, K; Arya, P The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. Bioorg Med Chem 16:7443-9 (2008) [PubMed] Article More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Mcl-1 | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mouse
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM50262596
Synonyms:
2-((2S,3R,4S)-4-(2-naphthamido)-1-(2-naphthoyl)-3-hydroxy-6-((2-methoxyethoxy)methoxy)-1,2,3,4-tetrahydroquinolin-2-yl)acetic acid | CHEMBL446860
Type:
Small organic molecule
Emp. Form.:
C37 H34 N2 O8
Mol. Mass.:
634.67446
SMILES:
COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc4ccccc4c3)c2c1)C(=O)c1ccc2ccccc2c1 |r|
Structure:
