Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Ligand
BDBM50262594
Substrate
n/a
Meas. Tech.
ChEMBL_489248 (CHEMBL989995)
Kd
100000±n/a nM
Citation
Prakesch, M; Denisov, AY; Naim, M; Gehring, K; Arya, P The discovery of small molecule chemical probes of Bcl-X(L) and Mcl-1. Bioorg Med Chem 16:7443-9 (2008) [PubMed] Article More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
Synonyms:
Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1
Type:
Developmental protein
Mol. Mass.:
35215.08
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
331
Sequence:
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Inhibitor
Name:
BDBM50262594
Synonyms:
(2S,3R,4S)-4-[(Biphenyl-4-carbonyl)-amino]-2-carboxymethyl-3-hydroxy-6-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-quinoline-1-carboxylic acid 2-trimethylsilanyl-ethyl ester | CHEMBL443599
Type:
Small organic molecule
Emp. Form.:
C34H42N2O9Si
Mol. Mass.:
650.7908
SMILES:
COCCOCOc1ccc2N([C@@H](CC(O)=O)[C@H](O)[C@@H](NC(=O)c3ccc(cc3)-c3ccccc3)c2c1)C(=O)OCC[Si](C)(C)C |r|
Structure:
