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Target
Prothrombin
Ligand
BDBM50273138
Substrate
n/a
Meas. Tech.
ChEMBL_510031 (CHEMBL995174)
Ki
>10000±n/a nM
Citation
 Uchida, M; Okazaki, K; Mukaiyama, H; Isawa, H; Kobayashi, H; Shiohara, H; Muranaka, H; Kai, Y; Kikuchi, N; Takeuchi, H; Yokoyama, K; Tsuji, E; Ozawa, T; Hoyano, Y; Koizumi, T; Misawa, K; Hara, K; Nakano, S; Murakami, Y; Okuno, H Orally active factor Xa inhibitors: investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy. Bioorg Med Chem Lett 18:4682-7 (2008) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50273138
Synonyms:
4-Hydroxy-3-[2-(4-isopropyl-phenyl)-ethylsulfamoyl]-benzamidine | CHEMBL463581
Type:
Small organic molecule
Emp. Form.:
C18H23N3O3S
Mol. Mass.:
361.459
SMILES:
CC(C)c1ccc(CCNS(=O)(=O)c2cc(ccc2O)C(N)=N)cc1
Structure:
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