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Target
C-C chemokine receptor type 4
Ligand
BDBM50245071
Substrate
n/a
Meas. Tech.
ChEMBL_512156 (CHEMBL628332)
IC50
280±n/a nM
Citation
 Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hattori, K; Miyazaki, T; Ogino, S; Orita, M; Matsumoto, Y; Takeuchi, M; Ohta, M Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines. Bioorg Med Chem 16:7968-74 (2008) [PubMed]  Article  BDB Entry
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CD_antigen=CD194 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50245071
Synonyms:
3-[(1-{4-[(4-Chlorophenyl)amino]-6,7-dimethoxyquinazolin-2-yl}piperidin-4-yl)(methyl)amino]propan-1-ol | CHEMBL488857
Type:
Small organic molecule
Emp. Form.:
C25H32ClN5O3
Mol. Mass.:
486.006
SMILES:
COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N(C)CCCO
Structure:
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