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Target
B1 bradykinin receptor
Ligand
BDBM50203205
Substrate
n/a
Meas. Tech.
ChEMBL_512956 (CHEMBL977292)
Ki
0.24±n/a nM
Citation
 Biswas, K; Aya, T; Qian, W; Peterkin, TA; Chen, JJ; Human, J; Hungate, RW; Kumar, G; Arik, L; Lester-Zeiner, D; Biddlecome, G; Manning, BH; Sun, H; Dong, H; Huang, M; Loeloff, R; Johnson, EJ; Askew, BC Aryl sulfones as novel bradykinin B1 receptor antagonists for treatment of chronic pain. Bioorg Med Chem Lett 18:4764-9 (2008) [PubMed]  Article 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM50203205
Synonyms:
(R)-3-(naphthalene-3-sulfonamido)-3-phenyl-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide | (R)-3-(naphthalene-7-sulfonamido)-3-phenyl-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide | CHEMBL218152
Type:
Small organic molecule
Emp. Form.:
C35H39N3O3S
Mol. Mass.:
581.767
SMILES:
O=C(C[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)c1ccccc1)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r|
Structure:
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