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Target
Calpain-2 catalytic subunit
Ligand
BDBM50263559
Substrate
n/a
Meas. Tech.
ChEMBL_535802 (CHEMBL991567)
IC50
99±n/a nM
Citation
 Shirasaki, Y; Takahashi, H; Yamaguchi, M; Inoue, J Molecular design to enhance the penetration into the retina via ocular instillation. Bioorg Med Chem Lett 18:5174-7 (2008) [PubMed]  Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain
Type:
n/a
Mol. Mass.:
37789.71
Organism:
Sus scrofa
Description:
n/a
Residue:
324
Sequence:
YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRISKQLDSENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50263559
Synonyms:
((1S)-1-((((1S)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2,3-DIOXOPROPYL)AMINO)CARBONYL)-3-METHYLBUTYL)CARBAMIC ACID 5-METHOXY-3-OXAPENTYL ESTER | 2-(2-methoxyethoxy)ethyl (S)-1-((S)-4-(cyclopropylamino)-3,4-dioxo-1-phenylbutan-2-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate | CHEMBL475920
Type:
Small organic molecule
Emp. Form.:
C25H37N3O7
Mol. Mass.:
491.5772
SMILES:
COCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 |r|
Structure:
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