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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50275922
Substrate
n/a
Meas. Tech.
ChEMBL_492850 (CHEMBL942181)
EC50
27±n/a nM
Citation
 Fracchiolla, G; Lavecchia, A; Laghezza, A; Piemontese, L; Trisolini, R; Carbonara, G; Tortorella, P; Novellino, E; Loiodice, F Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity. Bioorg Med Chem 16:9498-510 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Peroxisome proliferator-activated receptor | PPAR-alpha | Nuclear receptor subfamily 1 group C member 1 | PPAR alpha/gamma | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor alpha (PPAR alpha) | PPARA_HUMAN | PPARA | NR1C1 | PPAR
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Human
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50275922
Synonyms:
(S)-2-(4-chlorophenoxy)-3-(4-phenoxyphenyl)propanoic acid | CHEMBL472245
Type:
Small organic molecule
Emp. Form.:
C21 H17 Cl O4
Mol. Mass.:
368.81028
SMILES:
OC(=O)[C@H](Cc1ccc(Oc2ccccc2)cc1)Oc1ccc(Cl)cc1 |r|
Structure:
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