Target
C-C chemokine receptor type 4
Ligand
BDBM50245036
Substrate
n/a
Meas. Tech.
ChEMBL_558791 (CHEMBL1020785)
IC50
110±n/a nM
Citation
 Yokoyama, KIshikawa, NIgarashi, SKawano, NMasuda, NHamaguchi, WYamasaki, SKoganemaru, YHattori, KMiyazaki, TOgino, SMatsumoto, YTakeuchi, MOhta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem 17:64-73 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50245036
Synonyms:
CHEMBL486840 | N-(4-Chlorophenyl)-6,7-dimethoxy-2-(4-pyrrolidin-1-ylpiperidin-1-yl)quinazolin-4-amine
Type:
Small organic molecule
Emp. Form.:
C25H30ClN5O2
Mol. Mass.:
467.991
SMILES:
COc1cc2nc(nc(Nc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC1
Structure:
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