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Target
C-C chemokine receptor type 4
Ligand
BDBM50265760
Substrate
n/a
Meas. Tech.
ChEMBL_558791 (CHEMBL1020785)
IC50
180±n/a nM
Citation
 Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hamaguchi, W; Yamasaki, S; Koganemaru, Y; Hattori, K; Miyazaki, T; Ogino, S; Matsumoto, Y; Takeuchi, M; Ohta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem 17:64-73 (2008) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 4
Synonyms:
C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5
Type:
Enzyme
Mol. Mass.:
41406.41
Organism:
Homo sapiens (Human)
Description:
P51679
Residue:
360
Sequence:
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
  
Inhibitor
Name:
BDBM50265760
Synonyms:
CHEMBL499852 | [1'-(4-{[3-(4-Chlorophenyl)propyl]amino}-6,7-dimethoxyquinazolin-2-yl)-1,4'-bipiperidin-3-yl]methanol
Type:
Small organic molecule
Emp. Form.:
C30H40ClN5O3
Mol. Mass.:
554.123
SMILES:
COc1cc2nc(nc(NCCCc3ccc(Cl)cc3)c2cc1OC)N1CCC(CC1)N1CCCC(CO)C1
Structure:
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