Target
Histamine H3 receptor
Ligand
BDBM50255826
Substrate
n/a
Meas. Tech.
ChEMBL_515526
Ki
10±n/a nM
Citation
 Jablonowski, JALy, KSBogenstaetter, MDvorak, CABoggs, JDDvorak, LKLord, BMiller, KLMazur, CWilson, SJLovenberg, TWCarruthers, NI Novel imidazole-based histamine H3 antagonists. Bioorg Med Chem Lett 19:903-7 (2009) [PubMed]  Article
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50255826
Synonyms:
(4-chlorophenyl)(2-(1-isopropylpiperidin-4-yloxy)-1-methyl-1H-imidazol-5-yl)methanone | CHEMBL520100
Type:
Small organic molecule
Emp. Form.:
C19H24ClN3O2
Mol. Mass.:
361.866
SMILES:
CC(C)N1CCC(CC1)Oc1ncc(C(=O)c2ccc(Cl)cc2)n1C
Structure:
Search PDB for entries with ligand similarity: