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Target
Coagulation factor X
Ligand
BDBM35743
Substrate
n/a
Meas. Tech.
ChEMBL_516018 (CHEMBL981507)
Ki
8.77±n/a nM
Citation
 Nagata, T; Yoshino, T; Haginoya, N; Yoshikawa, K; Nagamochi, M; Kobayashi, S; Komoriya, S; Yokomizo, A; Muto, R; Yamaguchi, M; Osanai, K; Suzuki, M; Kanno, H Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa. Bioorg Med Chem 17:1193-206 (2009) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Coagulation factor X precursor | Factor Xa (fXa) | Stuart factor | FA10_RAT | F10
Type:
Enzyme
Mol. Mass.:
54255.03
Organism:
Rat
Description:
n/a
Residue:
482
Sequence:
MESPVRLSLLYVVLASLLLPGRSVFINRERANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVFEDNEKTTEFWNKYEDGDQCESSPCQNQGECRDGLGSYTCTCTEGFEGKNCELFVRKLCSLDNGDCDQFCREEQNSVVCSCAKGYFLGNDGKSCLSTAPFPCGKTNKGRAKRSVALNTSNSEPDPEDLMPDADILYPTESPSELLNLNKTEPEANSDDVIRIVGGQECKRGECPWQALLFSDEETDGFCGGTILNEFYILTAAHCLHQAKRFKVRVGDLNTEQEDGGEMVHEVDMIIKHNKFQRDTYDFDIAMLRLKTPITFRENVAPACLPQKDWAEATLMTQKTGIVSGFGRTHEKGRQSKVLKMMEVPYVDRNTCRLSTSFSITQNMFCAGYDAKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKARVGPTSETPRLTHPPY
  
Inhibitor
Name:
BDBM35743
Synonyms:
CHEMBL479863 | cis-1,2-diaminocyclohexane derivative, A
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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