Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 1
Ligand
BDBM50247972
Substrate
n/a
Meas. Tech.
ChEMBL_566227 (CHEMBL963308)
Ki
35±n/a nM
Citation
 Biju, P; Taveras, AG; Yu, Y; Zheng, J; Hipkin, RW; Fossetta, J; Fan, X; Fine, J; Lundell, D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett 19:1434-7 (2009) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 1
Synonyms:
C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:
Enzyme
Mol. Mass.:
39803.83
Organism:
Homo sapiens (Human)
Description:
P25024
Residue:
350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
  
Inhibitor
Name:
BDBM50247972
Synonyms:
(R)-2-hydroxy-N,N-dimethyl-3-(4-(1-(4-methylfuran-2-yl)propylamino)-1,2,5-thiadiazol-3-ylamino)benzamide | CHEMBL455209
Type:
Small organic molecule
Emp. Form.:
C19H23N5O3S
Mol. Mass.:
401.483
SMILES:
CC[C@@H](Nc1nsnc1Nc1cccc(C(=O)N(C)C)c1O)c1cc(C)co1 |r|
Structure:
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