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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50061564
Substrate
n/a
Meas. Tech.
ChEMBL_566261 (CHEMBL953564)
EC50
1995.26±n/a nM
Citation
 Enz, A; Feuerbach, D; Frederiksen, MU; Gentsch, C; Hurth, K; Müller, W; Nozulak, J; Roy, BL Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19:1287-91 (2009) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
Cholinergic, Nicotinic Alpha7 | NACHRA7 | nAChR7 | CHRNA7 | Nicotinic acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR) | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Human
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50061564
Synonyms:
3-[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-3,4,5,6-tetrahydro-[2,3']bipyridinyl | 3-(2,4-Dimethoxybenzylidene)anabaseine | (3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-3,4,5,6-TETRAHYDRO-2,3'-BIPYRIDINE | 3-[(2,4-dimethoxy)benzylidene]-anabaseine | 3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine | CHEMBL134713
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1ccc(c(c1)OC)\C=C\2/CCCN=C2c3cccnc3
Structure:
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