Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50249458
Substrate
n/a
Meas. Tech.
ChEMBL_499777 (CHEMBL968750)
IC50
610±n/a nM
Citation
 Moss, N; Choi, Y; Cogan, D; Flegg, A; Kahrs, A; Loke, P; Meyn, O; Nagaraja, R; Napier, S; Parker, A; Thomas Peterson, J; Ramsden, P; Sarko, C; Skow, D; Tomlinson, J; Tye, H; Whitaker, M A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties. Bioorg Med Chem Lett 19:2206-10 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50249458
Synonyms:
(4-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)(4-phenylcyclohexyl)methanone | CHEMBL472414
Type:
Small organic molecule
Emp. Form.:
C25H29N3O
Mol. Mass.:
387.5173
SMILES:
O=C(C1CCC(CC1)c1ccccc1)N1CCC(CC1)c1nc2ccccc2[nH]1 |(22.17,-46.12,;22.16,-44.58,;20.83,-43.81,;20.83,-42.28,;19.5,-41.51,;18.16,-42.28,;18.16,-43.82,;19.5,-44.59,;16.84,-41.51,;16.84,-39.96,;15.51,-39.19,;14.17,-39.96,;14.18,-41.51,;15.51,-42.27,;23.49,-43.8,;24.83,-44.58,;26.16,-43.81,;26.17,-42.27,;24.83,-41.5,;23.49,-42.27,;27.5,-41.51,;27.66,-39.98,;29.17,-39.66,;29.93,-38.33,;31.47,-38.33,;32.24,-39.67,;31.47,-41,;29.93,-40.99,;28.9,-42.14,)|
Structure:
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