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Target
Acetylcholine-binding protein
Ligand
BDBM50267883
Substrate
n/a
Meas. Tech.
ChEMBL_563557 (CHEMBL961844)
Ki
100±n/a nM
Citation
 Ulens, C; Akdemir, A; Jongejan, A; van Elk, R; Bertrand, S; Perrakis, A; Leurs, R; Smit, AB; Sixma, TK; Bertrand, D; de Esch, IJ Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. J Med Chem 52:2372-83 (2009) [PubMed]  Article 
Target
Name:
Acetylcholine-binding protein
Synonyms:
Acetylcholine Binding protein | Acetylcholine-binding protein (Ls-AchBP) | AchBP | Acetylcholine-binding protein (AchBP) | ACh-binding protein | ACHP_LYMST
Type:
n/a
Mol. Mass.:
26055.52
Organism:
Great pond snail
Description:
Soluble acetylcholine receptor
Residue:
229
Sequence:
MRRNIFCLACLWIVQACLSLDRADILYNIRQTSRPDVIPTQRDRPVAVSVSLKFINILEVNEITNEVDVVFWQQTTWSDRTLAWNSSHSPDQVSVPISSLWVPDLAAYNAISKPEVLTPQLARVVSDGEVLYMPSIRQRFSCDVSGVDTESGATCRIKIGSWTHHSREISVDPTTENSDDSEYFSQYSRFEILDVTQKKNSVTYSCCPEAYEDVEVSLNFRKKGRSEIL
  
Inhibitor
Name:
BDBM50267883
Synonyms:
8-Benzyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)-8-aza-bicyclo[3.2.1]octane | CHEMBL491861
Type:
Small organic molecule
Emp. Form.:
C29 H31 N O
Mol. Mass.:
409.56254
SMILES:
C(N1C2CCC1CC(C2)OC1c2ccccc2CCc2ccccc12)c1ccccc1
Structure:
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