Reaction Details Report a problem with these data
Target
Prolyl endopeptidase
Ligand
BDBM50279827
Substrate
n/a
Meas. Tech.
ChEBML_157466
Ki
2.4±n/a nM
KOFF
0.000300 s-1
KON
140000 M-1s-1
Citation
 Bakker, AV; Daffeh, J; Jung, S; Vincent, LA; Nagel, AA; Spencer, RW; Vinick, FJ; Faraci, WS Novel in vitro and in vivo inhibitors of prolyl endopeptidase Bioorg Med Chem Lett 1:585-590 (1991)    Article 
Target
Name:
Prolyl endopeptidase
Synonyms:
PE | Post-proline cleaving enzyme | PPCE_MOUSE | Prep | Pep
Type:
PROTEIN
Mol. Mass.:
80738.55
Organism:
Mouse
Description:
ChEMBL_1336164
Residue:
710
Sequence:
MLSFQYPDVYRDETSVQEYHGHKICDPYSWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNTLSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFTCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLCYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIWEGCDPVNRLWYCDLQQEPNGITGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRNSPNYRLINIDFTDPDESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSVVGYSGRKKDSEIFYQFTSFLSPGVIYHCDLTKEELEPMVFREVTVKGIDAADYQTIQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKFTIGHAWTTDYGCSDTKQHFEWLLKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIEWIQ
  
Inhibitor
Name:
BDBM50279827
Synonyms:
2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-2,3-dihydro-indole-1-carboxylic acid benzyl ester | CHEMBL345903
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: