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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50280157
Substrate
n/a
Meas. Tech.
ChEBML_4182
IC50
15000±n/a nM
Citation
 Brooks, DW; Schmidt, SP; Dyer, RD; Young, PR; Carter, GW Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase Bioorg Med Chem Lett 2:1309-1314 (1992)    Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
LOX5_RAT | Alox5 | Arachidonate 5-lipoxygenase
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rat
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50280157
Synonyms:
2-phenyl-1H-indene-1,3(2H)-dione | 2-Phenyl-1,3-indandione | 2-phenyl-1,3(2H)-Indenedione | 2-phenyl-1,3-diketohydrindene | PID | CHEMBL711 | PHENINDIONE
Type:
Small organic molecule
Emp. Form.:
C15 H10 O2
Mol. Mass.:
222.2387
SMILES:
c1ccc(cc1)C2C(=O)c3ccccc3C2=O
Structure:
Search PDB for entries with ligand similarity: