Target
Neutrophil elastase
Ligand
BDBM50285284
Substrate
n/a
Meas. Tech.
ChEMBL_86286 (CHEMBL698901)
Ki
0.08±n/a nM
Citation
 Desai, RCDunlap, RPFarrell, RPFerguson, EFranke, CAGordon, RHlasta, DJTalomie, TG Alkoxy substituted benzisothiazolone (BIT) derivatives: potent inhibitors of human leukocyte elastase Bioorg Med Chem Lett 5:105-109 (1995)    Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50285284
Synonyms:
2,6-Dichloro-benzoic acid 4,6-diethoxy-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL11874
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2NO7S
Mol. Mass.:
474.312
SMILES:
CCOc1cc2c(C(=O)N(COC(=O)c3c(Cl)cccc3Cl)S2(=O)=O)c(OCC)c1
Structure:
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