Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50285673
Substrate
n/a
Meas. Tech.
ChEMBL_99994 (CHEMBL710519)
IC50
1.16±n/a nM
Citation
 Labelle, M; Gareau, Y; Dufresne, C; Lau, CK; Belley, M; Jones, TR; Leblanc, Y; McAuliffe, M; McFarlane, CS; Metters, KM; Ouimet, N; Perrier, H; Rochette, C; Sawyer, N; Slipetz, D; Xiang, YB; Wang, Z; Pickett, CB; Ford-Hutchinson, AW; Young, RN Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist Bioorg Med Chem Lett 5:2551-2556 (1995)    Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
  
Inhibitor
Name:
BDBM50285673
Synonyms:
(1-{(R)-1-{3-[(E)-2-(2-Chloro-thieno[3,2-b]pyridin-5-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid | CHEMBL314340
Type:
Small organic molecule
Emp. Form.:
C33H34ClNO3S2
Mol. Mass.:
592.211
SMILES:
CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(O)=O)CC1)c1cccc(\C=C\c2ccc3sc(Cl)cc3n2)c1
Structure:
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