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Target
Endothelin-converting enzyme 1
Ligand
BDBM50288961
Substrate
n/a
Meas. Tech.
ChEBML_64369
IC50
6500±n/a nM
Citation
 Kukkola, PJ; Bilci, NA; Kozak, WX; Savage, P; Jeng, AY Optimization of retro-thiorphan for inhibition of endothelin converting enzyme Bioorg Med Chem Lett 6:619-624 (1996)    Article 
Target
Name:
Endothelin-converting enzyme 1
Synonyms:
ECE-1 | ECE1 | ECE1_HUMAN | Endothelin-Converting Enzyme 1 | Endothelin-converting enzyme 1 (ECE1)
Type:
Enzyme
Mol. Mass.:
87155.11
Organism:
Homo sapiens (Human)
Description:
P42892
Residue:
770
Sequence:
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
  
Inhibitor
Name:
BDBM50288961
Synonyms:
1-(2-Biphenyl-4-yl-acetyl)-piperidine-4-carboxylic acid [(R)-2-(1H-indol-3-yl)-1-mercaptomethyl-ethyl]-amide | CHEMBL345878
Type:
Small organic molecule
Emp. Form.:
C31H33N3O2S
Mol. Mass.:
511.678
SMILES:
SC[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCN(CC1)C(=O)Cc1ccc(cc1)-c1ccccc1
Structure:
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