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Target
Beta-1 adrenergic receptor
Ligand
BDBM25756
Substrate
n/a
Meas. Tech.
ChEBML_216165
IC50
190±n/a nM
Citation
 Iseki, K; Oishi, S; Sasai, H; Shibasaki, M SYNTHESIS AND BIOLOGICAL EVALUATION OF A FLUORINATED ANALOG OF THE β-ADRENERGIC BLOCKING AGENT, METOPROLOL Bioorg Med Chem Lett 7:1273-1274 (1997)    Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
adrenergic Beta1 | ADRB1 | Adrenergic receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50540.48
Organism:
Guinea pig
Description:
adrenergic Beta1 ADRB1 GUINEA PIG::B0FL73
Residue:
467
Sequence:
MGAGVLALGASEPCNLSSTAPLPDGAATAARLLVPASPPASLLPPTSEGSEPLSPQWTAGMGLLMVLIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARVLVCTVWAISALVSFLPILMHWWRAEGDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPGRPPSPVPSPTPGSPRAATDPLANGRTSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHTAHGGRPRASGCLARSGPPPSPGAASDEDEDAVGAAPPARLLEPWAGCNGGAATADSDWSLDEPGRAGFASESKV
  
Inhibitor
Name:
BDBM25756
Synonyms:
Betalok | Spesikor | {2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl}(propan-2-yl)amine | (2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol | metoprolol tartrate | CHEMBL13 | Spesicor | Metoprolol
Type:
Small organic molecule
Emp. Form.:
C15H25NO3
Mol. Mass.:
267.18
SMILES:
COCCc1ccc(OCC(O)CNC(C)C)cc1
Structure:
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