Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-5
Ligand
BDBM50290077
Substrate
n/a
Meas. Tech.
ChEMBL_69806 (CHEMBL677202)
IC50
2.7±n/a nM
Citation
 Olivier, A; Sevrin, M; Durant, F; George, P A conformational study of ligands for omega modulatory sites of GABAa receptors by NOESY NMR spectroscopy and distance geometry Bioorg Med Chem Lett 7:2277-2282 (1997)    Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-5
Synonyms:
GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA)
Type:
Enzyme
Mol. Mass.:
52160.59
Organism:
Homo sapiens (Human)
Description:
P31644
Residue:
462
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
  
Inhibitor
Name:
BDBM50290077
Synonyms:
CHEMBL73416 | N-[2-(4-Chloro-phenyl)-imidazo[1,2-a]pyridin-3-ylmethyl]-N-methyl-butyramide | Saripidem
Type:
Small organic molecule
Emp. Form.:
C19H20ClN3O
Mol. Mass.:
341.835
SMILES:
CCCC(=O)N(C)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: