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Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50294221
Substrate
n/a
Meas. Tech.
ChEMBL_574908 (CHEMBL1023605)
IC50
1100±n/a nM
Citation
 Kowalska, J; Lukaszewicz, M; Zuberek, J; Ziemniak, M; Darzynkiewicz, E; Jemielity, J Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett 19:1921-5 (2009) [PubMed]  Article 
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
IF4E_RABIT | EIF4E
Type:
PROTEIN
Mol. Mass.:
25047.40
Organism:
Rabbit
Description:
ChEMBL_1511842
Residue:
217
Sequence:
MATVEPETTPTPNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM50294221
Synonyms:
2-amino-9-[(2R,3R,4S,5R)-5-{[({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphinato]oxy}(sulfanidyl)phosphoryl)oxy]methyl}-3,4-dihydroxyoxolan-2-yl]-7-methyl-6-oxido-9H-purin-7-ium | CHEMBL555980
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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