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Target
Extracellular calcium-sensing receptor
Ligand
BDBM50299670
Substrate
n/a
Meas. Tech.
ChEMBL_592454 (CHEMBL1039645)
EC50
194±n/a nM
Citation
 Poon, SF; St Jean, DJ; Harrington, PE; Henley, C; Davis, J; Morony, S; Lott, FD; Reagan, JD; Lu, JY; Yang, Y; Fotsch, C Discovery and optimization of substituted 1-(1-phenyl-1H-pyrazol-3-yl)methanamines as potent and efficacious type II calcimimetics. J Med Chem 52:6535-8 (2009) [PubMed]  Article 
Target
Name:
Extracellular calcium-sensing receptor
Synonyms:
Parathyroid cell calcium-sensing receptor 1 | CaR | Extracellular calcium-sensing receptor | Calcium sensing receptor | Synonyms=GPRC2A | hCasR | Parathyroid Cell calcium-sensing receptor | CASR_HUMAN | CASR | GPRC2A | PCAR1 | Calcium-sensing receptor (CaSR)
Type:
Protein
Mol. Mass.:
120663.13
Organism:
Human
Description:
P41180
Residue:
1078
Sequence:
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
  
Inhibitor
Name:
BDBM50299670
Synonyms:
(R)-3-(2-chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine | [3-(2-Chloro-phenyl)-propyl]-[(R)-1-(3-methoxy-phenyl)-ethyl]-amine | CHEMBL292376
Type:
Small organic molecule
Emp. Form.:
C18 H22 Cl N O
Mol. Mass.:
303.82638
SMILES:
C[C@H](c1cccc(c1)OC)NCCCc2ccccc2Cl
Structure:
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