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Target
Cyclin-dependent kinase 5 activator 1
Ligand
BDBM50414916
Substrate
n/a
Meas. Tech.
ChEMBL_590314 (CHEMBL1054437)
IC50
1.4±n/a nM
Citation
 Kaller, MR; Zhong, W; Henley, C; Magal, E; Nguyen, T; Powers, D; Rzasa, RM; Wang, W; Xiong, X; Norman, MH Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors. Bioorg Med Chem Lett 19:6591-4 (2009) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 5
Synonyms:
Cyclin-dependent-like kinase 5 (CDK5) | Cell division protein kinase 5 | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit | Cyclin-dependent-like kinase 5 | CDK5_HUMAN | CDK5 | CDKN5 | PSSALRE
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Human
Description:
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Component 2
Name:
Cyclin-dependent kinase 5 activator 1
Synonyms:
TPKII regulatory subunit | Cyclin-dependent kinase 5 regulatory subunit 1 | CD5R1_HUMAN | CDK5R1 | CDK5R | NCK5A
Type:
Enzyme Subunit
Mol. Mass.:
34077.43
Organism:
Human
Description:
Q15078
Residue:
307
Sequence:
MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGGSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR
  
Inhibitor
Name:
BDBM50414916
Synonyms:
CHEMBL567005
Type:
Small organic molecule
Emp. Form.:
C21H22N2O5S2
Mol. Mass.:
n/a
SMILES:
CCCc1[nH]c(=O)c(cc1C(=O)OCC)-c1csc(CS(=O)(=O)c2ccccc2)n1
Structure:
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