Reaction Details Report a problem with these data
Target
P2Y purinoceptor 12
Ligand
BDBM50302455
Substrate
n/a
Meas. Tech.
ChEMBL_597610 (CHEMBL1050573)
Ki
1810±n/a nM
Citation
 Kortum, SW; Lachance, RM; Schweitzer, BA; Yalamanchili, G; Rahman, H; Ennis, MD; Huff, RM; TenBrink, RE Thienopyrimidine-based P2Y12 platelet aggregation inhibitors. Bioorg Med Chem Lett 19:5919-23 (2009) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 12
Synonyms:
ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:
Enzyme
Mol. Mass.:
39458.48
Organism:
Homo sapiens (Human)
Description:
Q9H244
Residue:
342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKSEFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFIIIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
  
Inhibitor
Name:
BDBM50302455
Synonyms:
1-(4-(4-(4-(biphenylcarbonyl)piperazin-1-yl)-6-ethylthieno[2,3-d]pyrimidin-2-yl)piperazin-1-yl)-2,2,2-trifluoroethanone | CHEMBL568772
Type:
Small organic molecule
Emp. Form.:
C31H31F3N6O2S
Mol. Mass.:
608.677
SMILES:
CCc1cc2c(nc(nc2s1)N1CCN(CC1)C(=O)C(F)(F)F)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccccc1
Structure:
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