Reaction Details Report a problem with these data
Target
Secreted frizzled-related protein 1
Ligand
BDBM50302906
Substrate
n/a
Meas. Tech.
ChEMBL_595663 (CHEMBL1041726)
EC50
7200±n/a nM
Citation
 Shi, M; Stauffer, B; Bhat, R; Billiard, J; Ponce-de-Leon, H; Seestaller-Wehr, L; Fukayama, S; Mangine, A; Moran, R; Krishnamurthy, G; Bodine, P; Gopalsamy, A Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors. Bioorg Med Chem Lett 19:6337-9 (2009) [PubMed]  Article 
Target
Name:
Secreted frizzled-related protein 1
Synonyms:
SFRP1_HUMAN | SFRP1 | FRP | FRP1 | SARP2
Type:
PROTEIN
Mol. Mass.:
35404.91
Organism:
Human
Description:
ChEMBL_1363191
Residue:
314
Sequence:
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
  
Inhibitor
Name:
BDBM50302906
Synonyms:
methyl 2-(2-(2-imino-4-oxothiazolidin-5-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate | CHEMBL569227
Type:
Small organic molecule
Emp. Form.:
C13 H15 N3 O4 S2
Mol. Mass.:
341.40589
SMILES:
COC(=O)c1c(C)c(C)sc1NC(=O)Cc1sc(N)nc1O
Structure:
Search PDB for entries with ligand similarity: