Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50305735
Substrate
n/a
Meas. Tech.
ChEMBL_604755 (CHEMBL1072549)
IC50
>60000±n/a nM
Citation
 Chen, JJ; Cole, DC; Ciszewski, G; Crouse, K; Ellingboe, JW; Nowak, P; Tawa, GJ; Berstein, G; Li, W Identification of a new class of small molecule C5a receptor antagonists. Bioorg Med Chem Lett 20:662-4 (2010) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM50305735
Synonyms:
CHEMBL595990 | N,N'-(1,2-phenylene)bis(N-methyl-1-phenylmethanesulfonamide)
Type:
Small organic molecule
Emp. Form.:
C22H24N2O4S2
Mol. Mass.:
444.567
SMILES:
CN(c1ccccc1N(C)S(=O)(=O)c1ccc(C)cc1)S(=O)(=O)c1ccc(C)cc1
Structure:
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