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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50307417
Substrate
n/a
Meas. Tech.
ChEMBL_610979 (CHEMBL1070310)
Ki
0.2±n/a nM
Citation
 Asada, M; Iwahashi, M; Obitsu, T; Kinoshita, A; Nakai, Y; Onoda, T; Nagase, T; Tanaka, M; Yamaura, Y; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies. Bioorg Med Chem 18:1641-58 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3
Type:
G-protein coupled receptor
Mol. Mass.:
40092.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
  
Inhibitor
Name:
BDBM50307417
Synonyms:
3-[2-({[1-(3-Fluorophenyl)-3-methylbutyl]amino}carbonyl)-4-(phenoxymethyl)phenyl]propanoic acid | CHEMBL600831
Type:
Small organic molecule
Emp. Form.:
C28H30FNO4
Mol. Mass.:
463.5405
SMILES:
CC(C)CC(NC(=O)c1cc(COc2ccccc2)ccc1CCC(O)=O)c1cccc(F)c1
Structure:
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