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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50307448
Substrate
n/a
Meas. Tech.
ChEMBL_610979 (CHEMBL628625)
Ki
0.67±n/a nM
Citation
 Asada, M; Iwahashi, M; Obitsu, T; Kinoshita, A; Nakai, Y; Onoda, T; Nagase, T; Tanaka, M; Yamaura, Y; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies. Bioorg Med Chem 18:1641-58 (2010) [PubMed]  Article  BDB Entry
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PGE receptor, EP3 isoform alpha | PTGER3 | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40092.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
  
Inhibitor
Name:
BDBM50307448
Synonyms:
3-[4-[(3-Cyanophenoxy)methyl]-2-({[1-(3,4-dimethoxyphenyl)-3-methylbutyl]amino}carbonyl)phenyl]propanoic acid | CHEMBL597367
Type:
Small organic molecule
Emp. Form.:
C31H34N2O6
Mol. Mass.:
530.6115
SMILES:
COc1ccc(cc1OC)C(CC(C)C)NC(=O)c1cc(COc2cccc(c2)C#N)ccc1CCC(O)=O
Structure:
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