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Target
Prostaglandin E synthase
Ligand
BDBM50313218
Substrate
n/a
Meas. Tech.
ChEMBL_616831 (CHEMBL1100215)
IC50
280±n/a nM
Citation
 Wang, J; Limburg, D; Carter, J; Mbalaviele, G; Gierse, J; Vazquez, M Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template. Bioorg Med Chem Lett 20:1604-9 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
Prostaglandin E2 synthase-1 ( mPGES-1) | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | PTGES_HUMAN | PTGES | MGST1L1 | MPGES1 | PGES | PIG12 | Prostaglandin E synthase/G/H synthase 2
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Human
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50313218
Synonyms:
4-Hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[e][1,2]thiazine-3-carboxylic acid(3',4'-dichloro-biphenyl-4-yl)-amide | CHEMBL1082146
Type:
Small organic molecule
Emp. Form.:
C22 H16 Cl2 N2 O4 S
Mol. Mass.:
475.34443
SMILES:
CN1C(C(=O)Nc2ccc(cc2)-c2ccc(Cl)c(Cl)c2)=C(O)c2ccccc2S1(=O)=O |t:21|
Structure:
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