Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50314812
Substrate
n/a
Meas. Tech.
ChEMBL_627234 (CHEMBL1110803)
EC50
41.5±n/a nM
Citation
 Li, JKennedy, LJShi, YTao, SYe, XYChen, SYWang, YHernández, ASWang, WDevasthale, PVChen, SLai, ZZhang, HWu, SSmirk, RABolton, SARyono, DEZhang, HLim, NKChen, BCLocke, KTO'Malley, KMZhang, LSrivastava, RAMiao, BMeyers, DSMonshizadegan, HSearch, DGrimm, DZhang, RHarrity, TKunselman, LKCap, MKadiyala, PHosagrahara, VZhang, LXu, CLi, YXMuckelbauer, JKChang, CAn, YKrystek, SRBlanar, MAZahler, RMukherjee, RCheng, PTTino, JA Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem 53:2854-64 (2010) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50314812
Synonyms:
2-((4-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(ptolyloxycarbonyl)amino)acetic acid | CHEMBL1088910
Type:
Small organic molecule
Emp. Form.:
C28H25ClN2O6
Mol. Mass.:
520.961
SMILES:
Cc1oc(nc1COc1ccc(CN(CC(O)=O)C(=O)Oc2ccc(C)cc2)cc1)-c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: