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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50315985
Substrate
n/a
Meas. Tech.
ChEMBL_625741 (CHEMBL1104418)
Ki
0.12±n/a nM
Citation
 Asada, M; Obitsu, T; Kinoshita, A; Nakai, Y; Nagase, T; Sugimoto, I; Tanaka, M; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett 20:2639-43 (2010) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3
Type:
G-protein coupled receptor
Mol. Mass.:
40092.50
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
365
Sequence:
MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
  
Inhibitor
Name:
BDBM50315985
Synonyms:
3-(4-((1H-pyrazol-1-yl)methyl)-2-(2-(methyl(phenyl)amino)ethoxy)phenyl)-N-(3,4-difluorophenylsulfonyl)propanamide | CHEMBL1090937
Type:
Small organic molecule
Emp. Form.:
C28H28F2N4O4S
Mol. Mass.:
554.608
SMILES:
CN(CCOc1cc(Cn2cccn2)ccc1CCC(=O)NS(=O)(=O)c1ccc(F)c(F)c1)c1ccccc1
Structure:
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